Novel features of early burst suppression predict outcome after birth asphyxia
نویسندگان
چکیده
Burst suppression patterns in the electroencephalogram are a reliable marker of recent severe brain insult. Here we analyze statistical properties of bursts occurring in 20 electroencephalographic recordings acquired from hypothermic asphyxic newborns in the hours immediately following birth. We show that the distributions of burst area and duration in these acute data predict later clinical outcome in both structural neuroimaging and neurodevelopment. Our findings indicate the first early electroencephalographic metrics that offer outcome prediction in asphyxic neonates undergoing hypothermia treatment.
منابع مشابه
Predictive value of early continuous amplitude integrated EEG recordings on outcome after severe birth asphyxia in full term infants.
The background pattern in single channel amplitude integrated EEG recordings (aEEG) was recorded in 47 infants within the first six hours after birth to see if this could predict outcome after birth asphyxia. The aEEG background pattern during the first six hours of life was continuous and of normal voltage in 26 infants. All these infants survived; 25 were healthy, one had delayed psychomotor ...
متن کاملNovel methods for predicting clinical outcome in neonates from clinical electroencephalography recordings
......................................................................................................................................... 23 1.1 The neonatal brain: conception to postnatal development ........................................ 24 1.1.1 Formation of the brain............................................................................................... 24 1.1.2 Neonatal cortical c...
متن کامل63-66- Vishnu-marker
Birth asphyxia is a leading cause of neonatal mortality in India. At present there is no reliable early marker to predict the outcome in these cases. We conducted this study to evaluate 8-hydroxy 2-deoxyguanosine (8-OHdG) as a biochemical marker for predicting outcome in perinatal asphyxia. Term neonates fulfilling the inclusion criteria were recruited in the study. Cord blood was collected imm...
متن کاملTo compare the outcome (early) of neonates with birth asphyxia in-relation to place of delivery and age at time of admission.
OBJECTIVE To determine the frequency of birth asphyxia and short-term (early) outcome in relation to age at admission and place of delivery. METHODS A descriptive cross-sectional study was conducted in the Paediatric Department, Neonatal Ward of Liaquat University Hospital (LUH) Hyderabad from January to December 2009. All babies were received at our nursery or delivered in LUH with birth asp...
متن کاملSerum copeptin and neuron specific enolase are markers of neonatal distress and long-term neurodevelopmental outcome
The objective of this study was to evaluate the early changes in serial serum levels of copeptin and neuron-specific enolase (NSE) in neonates diagnosed with birth asphyxia, and to determine whether these biomarkers measured in the first 168 hours after birth are predictive of long-term neurodevelopmental outcome. Copeptin and NSE levels were measured from serum samples collected 6, 12, 24, 48,...
متن کامل